Yong Chul Bae (배용철)

· Position: Professor

· E-mail: ycbae@knu.ac.kr

· Tel: 053)660-6860 / Fax: 053)426-7731

Research Interests:

Neural connection in trigeminal sensory and motor system / processing of orofacial pain in the brain stem

Ongoing projects:

· Processing mechanism of specific modality of nociception in the brain stem.

· Synaptic organization and connectivity of various types of primary afferents in the brain stem.

· Inhibitory control of hypoglossal motoneurons.

· Pain processing mechanism in the dental pulp.

Recent publications (2008-Present):

Cho YS, Mah W, Youn DH, Kim YS, Ko H-G, Bae JY, Kim YS, Bae YC. 2023. Increase of glutamate in satellite glial cells of the trigeminal ganglion in a rat model of craniofacial neuropathic pain. Front Neuroanat 17:1302373.

An SB, Cho YS, Park SK, Kim YS, Bae YC. 2023. Synaptic connectivity of the TRPV1-positive trigeminal afferents in the rat lateral parabrachial nucleus. Front Cell Neurosci 17:1162874.

Han HM, Jeong SY, Cho YS, Choi SY, Bae YC. 2022. Expression of Piezo2 in the Dental Pulp, Sensory Root, and Trigeminal Ganglion and Its Coexpression with Vesicular Glutamate Transporters. J Endod 48(11):1407-1413.

Kim H, Kim D, Cho Y, Kim K, Roh JD, Kim Y, Yang E, Kim SS, Ahn S, Kim H, Kang H, Bae Y, Kim E. 2022. Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming. Nat Commun 13(1):5051.

Cho YS, Han HM, Jeong SY, Kim TH, Choi SY, Kim YS, Bae YC. 2022. Expression of Piezo1 in the Trigeminal Neurons and in the Axons That Innervate the Dental Pulp. Front Cell Neurosci 16:945948.

Park SK, Cho YS, Kim JH, Kim YS, Bae YC. 2022. Ultrastructure of Rat Rostral Nucleus of the Solitary Tract Terminals in the Parabrachial Nucleus and Medullary Reticular Formation. Front Cell Neurosci 16:858617.

Cho YS, Ko HG, Han HM, Park SK, Moozhayil SJ, Choi SY, Bae YC, 2021. Vesicular glutamate transporter-immunopositive axons that coexpress neuropeptides in the rat and human dental pulp. Int Endod J 54(3):377-387.

Paik SK, Yoshida A, Bae YC. 2021. Development of γ-aminobutyric acid-, glycine-, and glutamate-immunopositive boutons on the rat genioglossal motoneurons. Brain Struct Funct 226(3):889-900.

Park SK, Choi SK, Kim YG, Choi SY, Kim JW, Seo SH, Lee JH, Bae YC. 2020. Parvalbumin-, substance P- and calcitonin gene-related peptide-immunopositive axons in the human dental pulp differ in their distribution of varicosities. Sci Rep 10(1):10672.

Bae YC, Yoshida A. 2020. Morphological foundations of pain processing in dental pulp. J Oral Sci 62(2):126-130.

Park SK, Devi AP, Bae JY, Cho YS, Ko HG, Kim DY, Bae YC. 2019. Synaptic connectivity of urinary bladder afferents in the rat superficial dorsal horn and spinal parasympathetic nucleus. J Comp Neurol 527(18):3002-3013.

Park SK, Hong JH, Jung JK, Ko HG, Bae YC. 2019. Vesicular Glutamate Transporter 1 (VGLUT1)- and VGLUT2-containing Terminals on the Rat Jaw-closing γ-Motoneurons. Exp Neurobiol 28(4):451-457.

Paik SK, Yoo HI, Choi SK, Bae JY, Park SK, Bae YC. 2019. Distribution of excitatory and inhibitory axon terminals on the rat hypoglossal motoneurons. Brain Struct Funct 244(5):1767-1779.

Han HM, Kim TH, Bae JY, Bae YC. 2019. Primary sensory neurons expressing tropomyosin receptor kinase A in the rat trigeminal ganglion. Neurosci Lett 690:56-60.

Bae JY, Mun CJ, Kim YS, Ahn DK, Bae YC. 2018. Quantitative ultrastructural analysis of fibers expressing parvalbumin, calretinin, calbindin D-28k, stage specific embryonic antigen-4, and phosphorylated neurofilament 200 in the peripheral sensory root of the rat trigeminal ganglion. J Comp Neurol 526(14):2204-2214.

Park SK, Ko SJ, Paik SK, Rah JC, Lee KJ, Bae YC. 2018. Vesicular glutamate transporter 1 (VGLUT1)- and VGLUT2-immunopositive axon terminals on the rat jaw-closing and jaw-opening motoneurons. Brain Struct Funct 223(5):2323-2334.

Bae JY, Lee JS, Ko SJ, Cho YS, Rah JC, Cho HJ, Park MJ, Bae YC. 2018. Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus. Brain Struct Funct 223(5):2259-2268.

Kim YS, Kim SK, Lee JS, Ko SJ, Bae YC. 2018. Expression of vesicular glutamate transporters in transient receptor potential ankyrin 1 (TRPA1)-positive neurons in the rat trigeminal ganglion. Brain Res 1690:31-39.

Mah W, Lee SM, Lee J, Bae JY, Ju JS, Lee CJ, Ahn DK, Bae YC. 2017. A role for the purinergic receptor P2X3 in astrocytes in the mechanism of craniofacial neuropathic pain. Sci Rep 7(1):13627,

Kim TH, Park SK, Choi SY, Lee JS, Bae YC. 2017. Morphological change of Parvalbumin-positive myelinated axons in the human dental pulp. J Endod 43(6):977-981.

Bae JY, Mah W, Rah JC, Park SK, Bae YC. 2016. Expression of glycine receptor alpha 3 in the rat trigeminal neurons and central boutons in the brainstem. Brain Struct Funct 221(9):4601-4613.

Park SK, Lee DS, Bae JY, Bae YC. 2016. Central connectivity of the chorda tympani afferent terminals in the rat rostral nucleus of the solitary tract. Brain Struct Funct 221(2):1125-1137

Kim YS, Kim TH, McKemy DD, Bae YC. 2015. Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)- positive dental afferents in the mouse. Neurosci 303:378-388.

Cho YS, Kim YS, Moozhayil SJ, Yang ES, Bae YC. 2015. The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, dental pulp. Neurosci 291:15-25.

Bae JY, Kim JH, Cho YS, Mah W, Bae YC. 2015. Quantitative analysis of afferents expressing subtance P, calcitonin gene-related peptide, isolectin B4, neurofilament 200, and Peripherin in the sensory root of the rat trigeminal ganglion. J Comp Neurol 523(1):126-138 .

Yang ES, Jin MU, Hong JH, Kim YS, Choi SY, Kim TH, Cho YS, Bae YC. 2014. Expression of vesicular glutamate transports VGLUT1 and VGLUT2 in the rat dental pulp and trigeminal ganglion following inflammation. PLoS One 9(10):e109723.

Park SK, Kim JH, Yang ES, Ahn DK, Moon C, Bae YC. 2014. Ultrastructure and synaptic connectivity of main and accessory olfactory bulb efferent projections terminating in the rat anterior piriform cortex and medial amygdala. Brain Struct Funct 219(5):1603-1613.

Kim YS, Park JH, Choi SJ, Bae JY, Ahn DK, McKemy DD, Bae YC. 2014. Central connectivity of transient receptor potential melastatin 8-expressiong axons in the brain stem and spinal dorsal horn. PLoS One 9:e94080.

Paik SK, Kwak MK, Bae JY, Yi HW, Yoshida A, Bae YC. 2012. GABA-, glycine-, and glutamate-immunopositive boutons on mesencephalic trigeminal neurons that innervate jaw-closing muscle spindles in the rat: ultrastructure and development. J Comp Neurol 520:3414-3427.

Lee SM, Cho YS, Kim TH, Jin MU, Ahn DK,Noguchi K, Bae YC. 2012. An ultrastructural evidence for the expression of transient receptor potential ankyrin 1 (TRPA1) in astrocytes in the rat trigeminal caudal nucleus. J Chem Neuroanat 45:45-49.

Kim YS, Jung HK, Kim CS, Ahn DK, Bae YC. 2012. Expression of transient receptor potential ankyrin 1 (TRPA1) in the human dental pulp. J Endod 38:1087-1092.

Paik SK, Kwak WK, Bae JY, Na YK, Park SY, Yi HW, Ahn DK, Ottersen OP, Yoshida A, Bae YC. 2012. Development of GABA-, glycine-, and glutamateimmunopositive boutons onto rat jaw-opening motoneurons. J Comp Neurol 520:1212-1226.

Paik SK, Kim SK, Choi SJ, Yang ES, Ahn SH, Bae YC. 2012. Vesicular glutamate transporters in axons that innervate the human dental pulp. J Endod 38:470-474.

Bae YC, Yoshida A. 2011. Ultrastructural basis for craniofacial sensory processing in the brainstem. Int Rev Neurobiol 97:99-141.

Paik SK, Park SK, Jin JK, Bae JY, Choi SJ, Yoshida A, Ahn DK, Bae YC. 2011. Ultrastructural analysis of glutamate-immunopositive synapses onto the rat jaw-closing motoneurons during postnatal development. J Neurosci Res 89:153-161.

Yeo EJ, Cho YS, Paik SK, Yoshida A, Park MJ, Ahn DK, Moon CI, Kim YS, Bae YC. 2010. Ultrastructural analysis of the synaptic connectivity of TRPV1-expressing primary afferent terminals in the rat trigeminal caudal nucleus. J Comp Neurol 518:4134-4146.

Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC. 2010. Expression of TRPA1 receptor in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 518:687-698.

Paik SK, Lee DS, Kim JY, BAE JY, Cho YS, Ahn DK, Yoshida A, Bae YC. 2010. Quantitative ultrastructural analysis of the neurofilament 200-positive axons in the rat dental pulp. J Endod 36:1638-1642.

Paik SK, Park KP, Lee SK, Ma SK, Cho YS, Kim YK, Rhyu IJ, Ahn DK, Yoshida A, Bae YC. 2009. Light and electron microscopic analysis of the somata and parent axons innervating the rat upper molar and lower incisor pulp. Neuroscience 162:1279-1286.

Paik SK, Lee HJ, Choi MK, Cho YS, Park MJ, Moritani M, Yoshida A, Kim YS, Bae YC. 2009. Ultrastructural analysis of glutamate-, GABA-, and glycine-immunopositive boutons from supratrigeminal premotoneurons in the rat trigeminal motor nucleus. J Neurosci Res 87:1115-1122.

Kim YS, Kim YJ, Paik SK, Cho YS, Kwon TG, Ahn DK, Kim SK, Yoshida A, Bae YC. 2009. Expression of metabotropic glutamate receptor mGluR5 in human dental pulp. J Endod 35:690-694.

Moon YS, Paik SK, Seo JH, Yi HW, Cho YS, Moritani M, Yoshida A, Ahn DK, Kim YS, Bae YC. 2008. GABA- and glycine-like immunoreactivity in axonal endings presynaptic to the vibrissa afferents in the cat trigeminal interpolar nucleus. Neuroscience 152:138-145.

Kim YS, Paik SK, Cho YS, Shin HS, Bae JY, Moritani M, Yoshida A, Ahn DK, Valtschanoff J, Hwang SJ, Moon C, Bae YC. 2008. Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat. J Comp Neurol 506:627-639.

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[Collaboratory works]

Kim HW, Shim SW, Zhao AM, Roh D, Han HM, Middleton SJ, Kim W, Chung S, Johnson E, Prentice J, Tacon M, Koel-Simmelink MJA, Wieske L, Teunissen CE, Bae YC, Bennett DLH, Rinaldi S, Davies AJ, Oh SB. 2023. Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons. Pain 164(10):2327-2342.

Tsutsumi Y, Sato F, Furuta T, Uchino K, Moritani M, Bae YC, Kato T, Tachibana Y, Yoshida A. 2023. The Cerebellar Cortex Receives Orofacial Proprioceptive Signals from the Supratrigeminal Nucleus via the Mossy Fiber Pathway in Rats. Cerebellum 22(4):663-679.

Lim SM, Ihn HJ, Kim JA, Bae JS, Kim JE, Bae YC, Shin HI, Kim TH, Park EK. 2023. Suppressive effects of (-)-tubaic acid on RANKL-induced osteoclast differentiation and bone resorption. Anim Cells Syst (Seoul) 27(1):1-9.

Kim S, Oh H, Choi SH, Yoo YE, Noh YW, Cho Y, Im GH, Lee C, Oh Y, Yang E, Kim G, Chung WS, Kim H, Kang H, Bae Y, Kim SG, Kim E. 2022. Postnatal age-differential ASD-like transcriptomic, synaptic, and behavioral deficits in Myt1l-mutant mice. Cell Rep 40(12):111398.

Yoo Taesun, Joshi S, Prajapati S, Cho YS, Kim Jinkyeong, Park Pil-Hoon, Bae YC, Kim Eunjoon, Kim SY. 2022. A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum. Front Mol Neurosci 15:938590.

Tsutsumi Y, Sato F, Furuta T, Uchino K, Moritani M, Bae YC, Kato T, Tachibana Y, Yoshida A. 2022. The Cerebellar Cortex Receives Orofacial Proprioceptive Signals from the Supratrigeminal Nucleus via the Mossy Fiber Pathway in Rats. Cerebellum (E-publish).

Yoshida A, Inoue M, Sato F, Morita Y, Tsutsumi Y, Furuta T, Uchino K, Akhter F, Bae YC, Tachibana Y, Inoue T. 2022. Efferent and afferent connections of supratrigeminal neurons conveying orofacial muscle proprioception in rats. Brain Struct Funct 227(1):111-129.

Bae M, Roh JD, Kim Y, Kim SS, Han HM, Yang E, Kang H, Lee S, Kim JY, Kang R, Jung H, Yoo T, Kim H, Kim D, Oh H, Han S, Kim D, Han J, Bae YC, Kim H, Ahn S, Chan AM, Lee D, Kim JW, Kim E. 2021. SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Mol Med 13(2):e12632.

Park G, Lee JY, Han HM, An HS, Jin Z, Jeong EA, Kim KE, Shin HJ, Lee J, Kang D, Kim HJ, Bae YC, Roh GS. 2021. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis 12(5):445.

Kwak H, Koh W, Kim S, Song K, Shin JI, Lee JM, Lee EH, Bae JY, Ha GE, Oh JE, Park YM, Kim S, Feng J, Lee SE, Choi JW, Kim KH, Kim YS, Woo J, Lee D, Son T, Kwon SW, Park KD, Yoon BE, Lee J, Li Y, Lee H, Bae YC, Lee CJ, Cheong E. 2020. Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus. Neuron 108(4):691-706.e10.

Lee J, Kim K, Cho JH, Bae JY, O'Leary TP, Johnson JD, Bae YC, Kim EK. 2020. Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. JCI Insight 5(16):e135412.

Shin W, Kim K, Serraz B, Cho YS, Kim D, Kang M, Lee EJ, Lee H, Bae YC, Paoletti P, Kim E. 2020. Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice. PLoS Biol 18(4):e3000717.

Park H, Choi Y, Jung H, Kim S, Lee S, Han H, Kweon H, Kang S, Sim WS, Koopmans F, Yang E, Kim H, Smit AB, Bae YC, Kim E. 2020. Splice-dependent trans-synaptic PTPδ-IL1RAPL1 interaction regulates synapse formation and non-REM sleep. EMBO J 39:e104150.

Zhang J, Chandrasekaran G, Li W, Kim DY, Jeong IY, Lee SH, Liang T, Bae JY, Choi I, Kang H, Maeng JS, Kim MK, Lee T, Park SW, Kim MJ, Kim HS, Ro H, Bae YC, Park HC, Choi EY, Choi SY. 2020. Wnt-PLC-IP3-Connexin-Ca2+ axis maintains ependymal motile cilia in zebrafish spinal cord. Nat Commun 11(1):1860.

Kim K, Shin W, Kang M, Lee S, Kim D, Kang R, Jung Y, Cho Y, Yang E, Kim H, Bae YC, Kim E. 2020. Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms. Elife 9:e54224.

Oh SJ, Lee JM, Kim HB, Lee J, Han S, Bae JY, Hong GS, Koh W, Kwon J, Hwang ES, Woo DH, Youn I, Cho IJ, Bae YC, Lee S, Shim JW, Park JH, Lee CJ. 2019. Ultrasonic Neuromodulation via Astrocytic TRPA1. Curr Biol 29(20):3386-3401.

Nam MH, Han KS, Lee J, Won W, Koh W, Bae JY, Woo J, Kim J, Kwong E, Choi TY, Chun H, Lee SE, Kim SB, Park KD, Choi SY, Bae YC, Lee CJ. 2019. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Rep 28(5):1154-1166.

Yoo YE, Yoo T, Lee S, Lee J, Kim D, Han HM, Bae YC, Kim E. 2019. Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility. Front Mol Neurosci 12:155.

Dantsuji M, Nakamura S, Nakayama K, Mochizuki A, Park SK, Bae YC, Ozeki M, Inoue T. 5-HT2A receptor activation enhances NMDA receptor-mediated glutamate responses through Src kinase in the dendrites of rat jaw-closing motoneurons. 2019. J Physiol 597(9):2565-2589.

Jung H, Park H, Choi Y, Kang H, Lee E, Kweon H, Roh JD, Ellegood J, Choi W, Kang J, Rhim I, Choi SY, Bae M, Kim SG, Lee J, Chung C, Yoo T, Park H, Kim Y, Ha S, Um SM, Mo S, Kwon Y, Mah W, Bae YC, Kim H, Lerch JP, Paik SB, Kim E. 2018. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Nat Neurosci. 21(9):1218-1228.

Li Y, Kim R, Cho YS, Song WS, Kim D, Kim K, Roh JD, Chung C, Park H, Yang E, Kim SJ, Ko J, Kim H, Kim MH, Bae YC, Kim E. 2018. Lrfn2-mutant mice display suppressed synaptic plasticity and inhibitory synapse development and abnormal social communication and startle response. J Neurosci. 38(26):5872-5887.

Um SM, Ha S, Lee H, Kim J, Kim K, Shin W, Cho YS, Roh JD, Kang J, Yoo T, Noh YW, Choi Y, Bae YC, Kim E. 2018. NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation. Cell Rep. 23(13):3839-3851.

Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y. 2018. Inhibition of GluR Current in Microvilli of Sensory Neurons via Na+-Microdomain Coupling Among GluR, HCN Channel, and Na+/K+ Pump. Front Cell Neurosci. 12:113.

Bae YS, Yoon SH, Han JY, Woo J, Cho YS, Kwon SK, Bae YC, Kim D, Kim E, Kim MH. 2018. Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration. Genes Brain Behav. 17(2):126-138.

Yoshida A, Moritani M, Nagase Y, Bae YC. 2017. Projection and synaptic connectivity of trigeminal mesencephalic nucleus neurons controlling jaw reflexes. J Oral Sci. 59(2):177-182.

Roh JD, Choi SY, Cho YS, Choi TY, Park JS, Cutforth T, Chung W, Park H, Lee D, Kim MH, Lee Y, Mo S, Rhee JS, Kim H, Ko J, Choi SY, Bae YC, Shen K, Kim E, Han K. 2017. Increased Excitatory Synaptic Transmission of Dentate Granule Neurons in Mice Lacking PSD-95-Interacting Adhesion Molecule Neph2/Kirrel3 during the Early Postnatal Period. Front Mol Neurosci. 22;10:81.

Ha S, Lee D, Cho YS, Chung C, Yoo YE, Kim J, Lee J, Kim W, Kim H, Bae YC, Tanaka-Yamamoto K, Kim E. 2016. Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors. J Neurosci. 30;36(48):12129-12143.

Hyun JH, Eom K, Lee KY, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH. 2015. Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol 593(16):3617-3643.

Li Y, Zhang P, Choi TY, Park SK, Park H, Lee EJ, Lee D, Roh JD, Mah W, Kim R, Kim Y, Kwon H, Bae YC, Choi SY, Craig AM, Kim E. Splicing-dependent trans-synaptic SALM3-LAR-RPTP interactions regulate excitatory synapse development and locomotion.2015. Cell Rep 12(10):1618-1630.

Chung G, Saito M, Kawasaki Y, Kawano T, Yin D, Lee S, Kogo M, Takada M, Bae YC, Kim JS, Oh SB, Kang Y. 2015.Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons. Eur J Neurosci 41(8):998-1012.

Chung W, Choi SY, Lee E, Park H, Kang J, Park H, Choi Y, Lee D, Park SG, Kim R, Cho YS, Choi J, Kim MH, Lee JW, Lee S, Rhim I, Jung MW, Kim D, Bae YC, Kim E. 2015. Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression. Nat Neurosci 18(3):435-443.

Park H, Han KS, Seo J, Lee J, David SM, Woo J, Chun H, Cho S, Bae JY, An H, Koh W, Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae YC, Choi SY, Lee CJ. 2015. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain 8:7 doi: 10.1186.

Tsuboi Y, Honda K, Bae YC, Shinoda M, Kondo M, Katagiri A, Echizenya S, Kamakura S, Lee J, Iwata K. 2014. Morphological and functional changes in regenerated primary afferent fibers following mental and inferior alveolar nerve transection. Eur J Pain 19(9):1258-1266.

Yoon BE, Woo J, Chun H, Jo S, Bae JY, An H, Min JO, Oh SJ, Han KS, Kim HY, Kim T, Kim YS, Bae YC, Lee CJ. 2014. Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition. J Physiol 592(Pt 22):4951-4968.

Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee da Y, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ. 2014. GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nature Medicine 20:886-896.

Chung MK, Cho YS, Bae YC, Lee J, Zhang X, Ro JY. 2014. Peripheral G protein-coupled inwardly rectifying potassium channels are involved in delta-opioid receptor-mediated anti-hyperalgesia in rat masseter muscle. Eur J Pain 18: 29-38.

Lee H, Lee JK, Bae YC, Yang SH, Okino N, Schuchman EH, Yamashita T, Bae JS, Jin HK. 2014. Inhibition of GM3 synthase attenuates neuropathology of Niemann-Pick disease Type C by affecting sphingolipid metabolism. Mol Cells 37: 161-171.

Park J, Lee J, Shim J, Han W, Lee J, Bae YC, Chung YD, Kim CH, Moon SJ. 2013. dTULP, the Drosophila melanogaster Homology of Tubby, regulates transient receptor potential channel localization in cilia. PLoS Genet 9: e1003814

Woo J, Kwon SK, Nam J, Choi S, Takahashi H, Krueger D, Park J, Lee Y, Bae JY, Lee D, Ko J, Kim H, Kim MH, Bae Yc, Chang S, Craig AM, Kim E. 2013. The adhesion protein IgSF9b in coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. J Cell Biol 201: 929-944.

Nahm M, Lee MJ, Parkinson W, Lee M, Kim H, Kim YJ, Kim S, Cho YS, Min BM, Bae YC, Broadie K, Lee S. 2013. Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron 77: 680-695.

Saito M, Toyoda H, Kawakami S, Sato H, Bae YC, Kang Y. 2012. Capsaicin induces theta-band synchronization between gustatory and autonomic insular cortices. J Neurosci 32: 13470-13487.

Woo DH, Han KS, Shim JW, Yoon BE, Kim E, Bae JY, Oh SJ, Hwang EM, Marmorstein AD, Bae YC, Park JY, Lee CJ. 2012. TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation. Cell 151: 25-40.

Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J, Ha S, Chung C, Jung ES, Cho YS, Park SG, Lee JS, Lee K, Kim D, Bae YC, Kaang BK, Lee MG, Kim E. 2012. Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486: 261-265.

Kim YH, Back SK, Davies AJ, Jeong HY, Jo HJ, Chu ng GH, Na HS, Bae YC, Kim SJ, Kim JS, Jung SJ, Oh SB. 2012. TRPV1 in GABAergic Interneurons Mediates Neuropathic Mechanical Allodynia and Disinhibition of the Nociceptive Circuitry in the Spinal Cord. Neuron 74:640-647.

Lee D, Lee HW, Hong S, Choi BI, Kim HW, Han SB, Kim IH, Bae JY, Bae YC, Rhyu IJ, Sun W, Kim H. 2012. Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity. J Biol Chem 287:15981-15995.

Tomita A, Kato T, Sato F, Haque T, Oka A, Yamamoto M, Ono T, Bae YC, Maeda Y, Sessle BJ, Yoshida A. 2012. Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats. Neuroscience 200:166-185.

Han XJ, Lee MJ, Yu GR, Lee ZW, Bae JY, Bae YC, Kang SH, Kim DG. 2012. Altered dynamics of ubiquitin hybrid proteins during tumor cell apoptosis. Cell Death & Disease 3:e255.

Gurung M, Moon DC, Choi CW, Lee JH, Bae YC, Kim J, Lee YC, Seol SY, Cho DT, Kim SI, Lee JC. 2011. Staphylococcus aureus produces membrane-derived vesicles that induce host cell death. PLoS One 6:e27958.

Kim HY, Chung G, Jo HJ, Kim YS, Bae YC, Jung SJ, Kim JS, Oh SB. 2011. Characterization of dental nociceptive neurons. J Dent Res 90:771-776.

Yang J. Seo J, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E. 2011. DGKi regulates presynaptic release during mGluR-dependent LTD. EMBO J 30:165-180.

Han S, Nam J, Li Y, Kim S, Cho SH, Cho YS, Choi SY, Choi J, Han K, Kim Y, Na M, Kim H, Bae YC, Choi SY, Kim E. 2010. Regulation of Dendritic Spines, Spatial Memory, and Embryonic Development by the TANC Family of PSD-95-Interactiing Proteins. J Neurosci 30:15102-15112.

Nahm M, Long AA, Paik SK, Kim S, Bae YC, Broadie K, Lee S. 2010. The Cdc42-selective GAP Rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. J Cell Biol 191:661-675.

Oh D, Han S, Seo J, Lee JR, Choi J, Groffen J, Kim K, Cho YS, Choi HS, Shin H, Woo J, Won H, Park SK, Kim SY, Jo J, Whitcomb DJ, Cho K, Kim H, Bae YC, Heisterkamp N, Choi SY, Kim E. 2010. Regulation of Synaptic Rac 1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins. J Neurosci 30:14134-14144.

Nahm M, Kim S, Paik SK, Lee M, Lee S, Lee ZH, Kim J, Lee D, Bae YC, Lee S. 2010. dCIP4 (Drosophila Cdc42-Interacting Protein 4) Restrains Synaptic Growth by Inhibiting the Secretion of the Retrograde Glass Bottom Boat Signal. J Neurosci 30:8138-8150.

Lida C, Oka A, Moritani M, Kato T, Haque T, Sato F, Nakamura M, Uchino K, Seki S, Bae YC, Takada K, Yoshida A. 2010. Corticofugal Direct Projections to Primary Afferent Neurons in the Trigeminal Mesencephalic Nucleus of Rats. Neuroscience 169:1739-1757.

Chang Z, Haque T, Iida C, Seki S, Sato F, Kato T, Uchino K, Ono T, Nakamura M, Bae YC, Yoshida A. 2009. Distribution of premotoneurons for jaw-closing and jaw-opening motor nucleus receiving contacts from axon terminals of primary somatosensory cortical neurons in rats. Brain Res 1275:43-53.

Kim MH, Choi J, Yang J, Chung W, Kim JH, Paik SK, Kim K, Han S, Won H, Bae YS, Cho SH, Seo J, Bae YC, Choi SY, Kim EJ. 2009. Enhanced NMDA Receptor-Mediated Synaptic Transmission, Enhanced Long-Term Potentiation, and Impaired Learing and Memory in Mice Lacking IRSp53. J Neurosci 29:1586-1595.

Kim YH, Park CK, Back SK, Lee CJ, Hwang SJ, Bae YC, Na HS, Kim JS, Jung SJ, Oh SB. 2009. Membrane-delimited coupling of TRPV1 and mGluR5 on presynaptic terminals of nociceptive neurons. J Neurosci 29:10000-10009.

Kim K, Yang J, Zhong XP, Kim MH, Kim YS, Lee HW, Han S, Choi J, Han K, Seo J, Prescott SM, Topham MK, Bae YC, Koretzky G, Choi SY, Kim E. 2009. Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. EMBO J 28:1170-1179.

Lee M, Paik SK, Lee MJ, Kim YJ, Kim S, Nahm M, Oh SJ, Kim HM, Yim J, Lee CJ, Bae YC, Lee S. 2009. Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development. Dev Biol 330:250-62.

Biography:
 · 1983. 02. 경북대학교 치과대학 치의학과 졸업
 · 1990. 08. 경북대학교 대학원 치의학박사
 · 1996. 06. 일본 오사카대학 치학박사
 · present. 경북대학교 치의학전문대학원 교수

Yun Sook Kim ( 김윤숙 )

· Position: Assistant Professor

· E-mail: yunskim@knu.ac.kr

· Tel: 053)660-6863

Research Interests:

· Pain transmission

Ongoing projects:

· TRP channels in human tooth pulp

Recent publications (2008-Present):

Bae JY, Mun CJ, Kim YS, Ahn DK, Bae YC. 2018. Quantitative ultrastructural analysis of fibers expressing parvalbumin, calretinin, calbindin D-28k, stage specific embryonic antigen-4, and phosphorylated neurofilament 200 in the peripheral sensory root of the rat trigeminal ganglion. J Comp Neurol. In Press.

Kim YS, Kim SK, Lee JS, Ko SJ, Bae YC. 2018. Expression of vesicular glutamate transporters in transient receptor potential ankyrin 1 (TRPA1)-positive neurons in the rat trigeminal ganglion. Brain Res. 1690;31-39.

Kim YS, Kim TH, McKemy DD, Bae YC. 2015. Expression of vesicular glutamate transporters in transient receptor potential melastatin 8 (TRPM8)- positive dental afferents in the mouse. Neurosci 303:378-388.

Cho YS, Kim YS, Moozhayil SJ, Yang ES, Bae YC. 2015. The expression of hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and HCN2 in the rat trigeminal ganglion, sensory root, dental pulp. Neurosci 291:15-25.

Yang ES, Jin MU, Hong JH, Kim YS, Choi SY, Kim TH, Cho YS, Bae YC. 2014. Expression of vesicular glutamate transports VGLUT1 and VGLUT2 in the rat dental pulp and trigeminal ganglion following inflammation. PLoS One 9(10):e109723

Kim YS, Park JH, Choi SJ, Bae JY, Ahn DK, McKemy DD, Bae YC. 2014. Central connectivity of transient receptor potential melastatin 8-expressiong axons in the brain stem and spinal dorsal horn. PLoS One 9:e94080

Kim YS, Jung HK, Kim CS, Ahn DK, Bae YC. 2012. Expression of transient receptor potential ankyrin 1 (TRPA1) in the human dental pulp. J Endod 38:1087-1092.

Yeo EJ, Cho YS, Paik SK, Yoshida A, Park MJ, Ahn DK, Moon CI, Kim YS, Bae YC. 2010. Ultrastructural analysis of the synaptic connectivity of TRPV1-expressing primary afferent terminals in the rat trigeminal caudal nucleus. J Comp Neurol 518:4134-4144.

Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC. 2010. Expression of TRPA1 receptor in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol 518:687-698.

Kim YS, Kim YJ, Paik SK, Cho YS, Kwon TG, Ahn DK, Kim SK, Yoshida A, Bae YC. 2009. Expression of metabotropic glutamate receptor mGluR5 in human dental pulp. J Endod 35:690-694.

Moon YS, Paik SK, Seo JH, Yi HW, Cho YS, Moritani M, Yoshida A, Ahn DK, Kim YS, Bae YC. 2008. GABA- and glycine-like immunoreactivity in axonal endings presynaptic to the vibrissa afferents in the cat trigeminal interpolar nucleus. Neuroscience 152:138-145.

Kim YS, Paik SK, Cho YS, Shin HS, Bae JY, Moritani M, Yoshida A, Ahn DK, Valtschanoff J, Hwang SJ, Moon C, Bae YC. 2008. Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat. J Comp Neurol 506:627-639.